In the case of delrin, there should be virtually no contact between the smoker, the smoke and glue. I make pipe stems with both types of tenons. If the delrin is inserted properly into the rod stock/stem there will be no glue in contact with the airway. I like the feel of a delrin tenon (and the strength, it's extremely durable), but a good integral tenon will be smooth too. I think it mostly comes down to personal preference.
Just for your reference, most of the carvers I know (the ones that use delrin) make their tenons from long pieces of delrin rod (3' lengths). You can buy tenons from some carving/repair suppliers, but I don't know of many guys who do this. There are quite a few steps in making a proper tenon, so the pre-made versions don't really save you much. More of a practicality/money issue than anything.